Thursday, January 17, 2013


Dear esteemed members of the OSDD community,
It is with pleasure that we inform the OSDD community that OSDD has established a CSIR-OSDD Research Unit at Indian Institute of Science (IISc), Bangalore; as an open lab for facilitating OSDD’s drug discovery efforts. The facility was dedicated to the OSDD community by Dr. P. Balaram, Director, IISc in the presence of Prof. S. K. Brahmachari, Chief Mentor OSDD, Sir Tom Blendell, Cambridge University and Dr. T.S. Balganesh, Head OSDD Unit.
                  OSDD Research Unit @ IISc is an open lab where any member of OSDD community is welcome to come in and spent time on any research problem posted on the Sysborg portal. Dr. T.S. Balganesh, Head OSDD Unit and renowned scientist on TB drug discovery will be functioning from the Unit and will be available for guidance. Dr. U.C. Jaleel ( will be the PI in charge of the Unit.
  As there will be requests from multiple PI’s and as a number of collaborative projects with IISc is also expected, you are requested to inform Dr. Jaleel in advance to book your slot for your research visit. You will always be served on a ‘first come first served’ basis. The address of the Unit is 2nd Floor Society for Innovation and Development building, Indian Institute of Science, Bangalore. You may contact the Unit by calling the OSDD helpline 
080 23603411.
                The Unit also invites researchers on TB, Malaria, drug discovery and development to spent short sabbatical periods doing specific projects of interest to the OSDD community.
                As with all OSDD efforts, this Unit is dedicated to the neglected patients around the world.
 With warm regards   Zakir Thomas Project Director, OSDD

Monday, February 6, 2012

Open Source Drug Discovery (OSDD) is organizing 2nd International conference on open source for computer-aided Translational medicine, at Institute of Microbial Technology, Chandigarh, India. This conference will be useful for scientific community working in the field of drug discovery particularly on Mycobacterium tuberculosis. This conference will be organized in February 2012 (22nd to 25th Feb.). Following are major objectives of this conference
  • Promoting open source in therapeutics.
  • Role of computer in translational research.
  • Integration of in silico & wet-lab experiments.
  • Bring wide range of experts (in silico to clinical) on single platform.
  • Discuss current status of therapeutics in tuberculosis.
CSIR-Institute of Microbial Technology, Chandigarh
Importance of Translational Medicine: Despite tremendous progress in the field of medicine, research are unable to discover/develop effective medicine against various dread diseases. Due to lack of effective medicine, we have several millions of immature deaths every year world-wide. Thus their is a need to promote translational research (transforming basic research into medicines), in order to improve quality of life. Translational medicine needs wide range of expertise from basic science to clinical (bench to bedside). In this conference attempt will be made to bring wide range of experts on single platform, who are directly or indirectly working in the field of translational research in therapeutics.

Open Source for Drug Discovery (OSDD)OSDD Forum is an initiative with a vision to provide affordable healthcare to the developing world. The OSDD concept aims to synergize the power of genomics, computational technologies and facilitate the participation of young and brilliant talent from universities and industry. It seeks to provide a global platform where the best brains can collaborate and collectively endeavor to solve the complex problems associated with discovering novel therapies for neglected diseases particularly Tuberculosis.

Thursday, October 13, 2011

OSDD-Madars University uploaded next molecule


 DrHaridas Rode  Scientist  CSIR HQ, New Delhi-01 -- OSDD ORGANIC CHEMISTRY 


Chief Mentor 
Prof S K Brahmachari 
Project Director

Zakir Thomas
                                                      Dr.Tushar Kanti Chakraborty (TKC), (CDRI)

Chemistry Team -
Lead by - Dr. Sanjay Batra (SB), CDRI
               Dr. Saman Habib (SH), CDRI
               Dr. Haridas Rode (HR), CSIR

Cheminformatics Team -
Lead by - Dr. UC Jaleel (UCJ)
            - Ms. Geetha Sugumaran

            - Mr. Sonu KP

Informatics Team - 
Lead by - Dr. GPS Raghava (GPSR), IMT
              Dr. Anshu Bhardwaj (AB), CSIR

Design and database architecture -

Implementation of Design -
Mr. Arun Sharma, IMT

Design of the website-
Mr. Biju CG

Wednesday, October 5, 2011

OSDD -"Antimalarials: Current Approaches and New Directions"

Dear All,
A one day symposium on "Antimalarials: Current Approaches and New Directions" is being organized jointly by Medicines for Malaria Venture (MMV) and Open Source Drug Discovery malaria (OSDDm) at CSIR-Central Drug Research Institute, Lucknow on 16th November, 2011. This is an effort to apprise the principal investigators joining the OSDDm platform of the latest developments in the design and discovery of new antimalarials. The conference will include lectures by Prof. Stephen Ward, Walter Myers Professor of Parasitology and Deputy Director at Liverpool School of Tropical Medicine and Dr. Jeremy Burrows, Head of Discovery at MMV, Switzerland besides eminent medicinal chemists and biochemists from India working in the area of development of chemotherapy for malaria.
We cordially invite you participate in the symposium. The organizing committee will be happy to provide accommodation on twin sharing basis and local hospitality. However due to constraints in funding, travel expenses need to be borne by participants.
We look forward to receiving a line of confirmation towards your participation as soon as possible.

With best regards,


Sanjay Batra, PhD
Medicinal Chemistry Division,
Central Drug Research Institute,
PO Box 173, Lucknow 226001
Ph. +91-522-2612411-18 Extn 4234,4368
Fax. +91-522-2623405, 2623938
Cell +91-9450906193

in photo  dr saman leader OSDDm @PI conference  osdd day
posted by osddwomen 

Friday, September 23, 2011

IIRBS donated first molecule to osdd chem


                                       OSDD IIRBS CONSORTIUM

Friday, September 16, 2011


         15th September 2011, Venue: CSIR HQ
  • Brain Storming Session on OSDD: 10.00-1.30 PM
  • Introductory Remarks: Project Director (10.00-10.30 AM)
  • Coordinating OSDD Activities: Led by Dr Balganesh (10.30 – 11.00 AM)
  • Comments: Chief Mentor (11.00 -11.30 AM)
  • Lead Optimization and Library Screening Projects (Coordinator Dr Geetha Vani)
  • Dr Sudhir Sinha/Dr. Tushar Chakarborty - Proposal for Preclinical Development of Thiophene Compounds (11.30 – 12.00 noon)
  • Dr Rajesh Gokhale - Multi target system based approach to drug discovery (12.00 –12.30 PM)
  •  Dr Inshad Ali Khan/Amit Nargotra - Whole Cell Screening of library of drug like compounds from Chembridge database (12.30 - 1.00 PM)
  •  Dr Nagasuma Chandra - Systems Level Pharmacodynamic Modelling to Predict
  • Therapy Outcome (1.00 -1.20 PM)
  • Lunch Break 1.30- 2.30 PM
  • Seminar on Affordable Health Care for All: 2.30-5.30 PM

       16th September 2011,Venue: Science Centre, Gate No.2 Lodhi Garden

       Bioinformatics Projects (Coordinator Dr Anshu Bhardwaj)
  •  Dr Anshu Bhardwaj - Interactome and metabolic construction of Mtb, Generating resources both in terms of data and tools for better evaluation of potential drug targets (10.00 – 10.20 AM)
  • Dr Andrew Lynn- Hosted Methods for OSDD Communities; OSDD Portal Development Project (10.20 – 10.40 AM)
  • Dr GPS Raghava – Webservers and software in the field of cheminformatics and pharmacoinformatics (10.40 -11.00 AM)

Tea Break (11.00-11.20 AM)

  • Dr Nanda Ghosal - Designing potential lead molecules for inhibition of siderophore biosynthesis in Mtb (11.20 -11.40 AM)
  • Dr U.C. Jaleel – Cheminformatics (11.40 -12.00 PM)
  • Dr Amit Mishra: Transcript Profiling of Macrophages Exposed to TB Drugs and Drug Microparticle (12.00 – 12.20 PM)
  • Dr Vinod Scaria – Chieminformatics and Genome Annotation (12.00 – 12.20 PM)
  • Dr Haridas Rode – A resource of anti TB phytomolecules (12.20 – 12.40 PM)

Lunch (1.00 – 2.00 PM)    

         Biology Projects (Coordinator Dr Geetha Vani Rayasam)

  • Dr Sridhar Sivasubu & Dr Swati Subodh – Sequencing of MTb strains (2.00 -2.20
  • Dr Devendra Chauhan- JALMA MTb Strains (2.20 -2.30 PM)
  • Dr M Vijaylakshmi/Dr Sadhna Sharma/Dr Urmi Bajpai – Cloning and Expression of the select Mycobacterium Tuberculosis Genes (2.30 -2.50 PM)
  • Dr. K.K. Srivastava- Drug target based screens (2.50 – 3.10 PM)
  • Dr. Javed Aggrewala - Regression of the growth of M. tuberculosis by lipidated promiscuous peptide (3.10 - 3.30 PM)

Tea Break (3.30 - 4.00 PM)

  • Dr. Ashwini Kumar- System to validate protein-protein interactions (PPIs) (4.00 -4.20 PM)
  • Dr Gobardhan Das - Immunomodulation as a therapeutic approach (4.20 – 4.40 PM)
  • Dr Vinod Scaria – Chieminformatics and Genome Annotation (4.40 -5.00 PM)
  • Dr Debasis Dash - Mycobacterium tuberculosis GlmURv1018c as potential Drug Target (5.00 - 5.20 PM)
  • Dr Avinash Sonawane - Construction of GlmU mutants and Understanding the effect of Mutation or Deletion of C-terminus amino acid stretch involved in Protein-Ligand Interaction (5.20-5.40 PM)
  • Dr Balaji Prakash- Crystal structure analysis of GlmU (5.40-6.00 PM)
  • Dr B Siram: Design and synthesis of new inhibitors of Mycobacterium tuberculosis GlmU (6.00-6.20 PM)
  • Dr Vinay Nandicoori - Assay Development and Hit Identification for GlmU (6.20-6.40
  • Dr Y. Singh: Protein kinases as a drug targets in Mycobacteria (6.40-7.00 PM)
  • Dr Vinay Nandicoori: Assay Development and Hit Identification of PKNB inhibitors (7.00-7.20PM)
  • OSDD Students: Presentations and Interaction (7.20-8.00 PM)

     17th September 2011 , Venue: Science Centre, Gate No.2 Lodhi Garden

     Chemistry & Early Hit Identification (Coordinator Dr. Haridas Rode)

  • Dr Tushar Chakraborty - Open Chemistry + Outreach program (10.00 – 10.20 AM )
  • Dr. Radhakrishnan – Outreach Program (10.20 – 10.40 AM )
  • Dr Anamik Shah - Organic synthesis (10.40 – 10.50 AM )
  • Dr Nagaraju - Exploring the medicinal plants of the Western Ghats for potential drug molecules that possess ant-microbial activity and synthesis of a few molecules derived from lead compounds (10.50 – 11.00 AM )
  • Dr S V Eeshwaran - Substituted Aryl/Biaryl Triazoles and Quinoxalines as pontential Anti-tubercularagents (11.00 – 11.10 AM )
  • Dr Anil Kumar - Small molecule inhibitors of Mycobacterial Menaquionine biosynthetic pathway enzymes as novel anti-TB drugs; Improved Chemical Entitites as Anti-Tubercular Agents Targeting the Respiratory Pathway through Co-Crystal Engineering (11.10 – 11.20 AM)
  • Rev Fr Dr S Ignacimuthu - Isolation of antimycobacterial compounds vasicine acetate and 2-acetyl benzylamine from adhatoda vasica and synthesis (11.20 –11.30 AM )

 Tea Break (11.30 – 11.50 AM)

  • Dr Pemaiah Brindha - Screening of Anti-Tubercular Compounds from Plant Resources (11.50– 12.00 Noon)
  • Dr Saraswathi R – Nano particle based drug delivery (12.00 -12.10 PM)
  • Dr. Surinder Koul - MDR resistant efflux pump Rv1258c of Mtb (12.10 -12.30 PM)
  • Dr G.P.S Raghav: Prediction of Dap A and Dap B inhibitors (12.30-12.50 PM)
  • Dr S. Ramachandran: Development of assays for Dap A and Dap B (12.50-1.10 PM)
  • Dr Bala Pesala/Dr Ashwini Kumar: Non invasive optical TB diagnostics (1.10-1.30
  • Dr. Saman Habib: OSDD – Malaria (1.30-1.50 PM)