Thursday, October 13, 2011

OSDD-Madars University uploaded next molecule


 DrHaridas Rode  Scientist  CSIR HQ, New Delhi-01 -- OSDD ORGANIC CHEMISTRY 


Chief Mentor 
Prof S K Brahmachari 
Project Director

Zakir Thomas
                                                      Dr.Tushar Kanti Chakraborty (TKC), (CDRI)

Chemistry Team -
Lead by - Dr. Sanjay Batra (SB), CDRI
               Dr. Saman Habib (SH), CDRI
               Dr. Haridas Rode (HR), CSIR

Cheminformatics Team -
Lead by - Dr. UC Jaleel (UCJ)
            - Ms. Geetha Sugumaran

            - Mr. Sonu KP

Informatics Team - 
Lead by - Dr. GPS Raghava (GPSR), IMT
              Dr. Anshu Bhardwaj (AB), CSIR

Design and database architecture -

Implementation of Design -
Mr. Arun Sharma, IMT

Design of the website-
Mr. Biju CG

Wednesday, October 5, 2011

OSDD -"Antimalarials: Current Approaches and New Directions"

Dear All,
A one day symposium on "Antimalarials: Current Approaches and New Directions" is being organized jointly by Medicines for Malaria Venture (MMV) and Open Source Drug Discovery malaria (OSDDm) at CSIR-Central Drug Research Institute, Lucknow on 16th November, 2011. This is an effort to apprise the principal investigators joining the OSDDm platform of the latest developments in the design and discovery of new antimalarials. The conference will include lectures by Prof. Stephen Ward, Walter Myers Professor of Parasitology and Deputy Director at Liverpool School of Tropical Medicine and Dr. Jeremy Burrows, Head of Discovery at MMV, Switzerland besides eminent medicinal chemists and biochemists from India working in the area of development of chemotherapy for malaria.
We cordially invite you participate in the symposium. The organizing committee will be happy to provide accommodation on twin sharing basis and local hospitality. However due to constraints in funding, travel expenses need to be borne by participants.
We look forward to receiving a line of confirmation towards your participation as soon as possible.

With best regards,


Sanjay Batra, PhD
Medicinal Chemistry Division,
Central Drug Research Institute,
PO Box 173, Lucknow 226001
Ph. +91-522-2612411-18 Extn 4234,4368
Fax. +91-522-2623405, 2623938
Cell +91-9450906193

in photo  dr saman leader OSDDm @PI conference  osdd day
posted by osddwomen 

Friday, September 23, 2011

IIRBS donated first molecule to osdd chem


                                       OSDD IIRBS CONSORTIUM

Friday, September 16, 2011


         15th September 2011, Venue: CSIR HQ
  • Brain Storming Session on OSDD: 10.00-1.30 PM
  • Introductory Remarks: Project Director (10.00-10.30 AM)
  • Coordinating OSDD Activities: Led by Dr Balganesh (10.30 – 11.00 AM)
  • Comments: Chief Mentor (11.00 -11.30 AM)
  • Lead Optimization and Library Screening Projects (Coordinator Dr Geetha Vani)
  • Dr Sudhir Sinha/Dr. Tushar Chakarborty - Proposal for Preclinical Development of Thiophene Compounds (11.30 – 12.00 noon)
  • Dr Rajesh Gokhale - Multi target system based approach to drug discovery (12.00 –12.30 PM)
  •  Dr Inshad Ali Khan/Amit Nargotra - Whole Cell Screening of library of drug like compounds from Chembridge database (12.30 - 1.00 PM)
  •  Dr Nagasuma Chandra - Systems Level Pharmacodynamic Modelling to Predict
  • Therapy Outcome (1.00 -1.20 PM)
  • Lunch Break 1.30- 2.30 PM
  • Seminar on Affordable Health Care for All: 2.30-5.30 PM

       16th September 2011,Venue: Science Centre, Gate No.2 Lodhi Garden

       Bioinformatics Projects (Coordinator Dr Anshu Bhardwaj)
  •  Dr Anshu Bhardwaj - Interactome and metabolic construction of Mtb, Generating resources both in terms of data and tools for better evaluation of potential drug targets (10.00 – 10.20 AM)
  • Dr Andrew Lynn- Hosted Methods for OSDD Communities; OSDD Portal Development Project (10.20 – 10.40 AM)
  • Dr GPS Raghava – Webservers and software in the field of cheminformatics and pharmacoinformatics (10.40 -11.00 AM)

Tea Break (11.00-11.20 AM)

  • Dr Nanda Ghosal - Designing potential lead molecules for inhibition of siderophore biosynthesis in Mtb (11.20 -11.40 AM)
  • Dr U.C. Jaleel – Cheminformatics (11.40 -12.00 PM)
  • Dr Amit Mishra: Transcript Profiling of Macrophages Exposed to TB Drugs and Drug Microparticle (12.00 – 12.20 PM)
  • Dr Vinod Scaria – Chieminformatics and Genome Annotation (12.00 – 12.20 PM)
  • Dr Haridas Rode – A resource of anti TB phytomolecules (12.20 – 12.40 PM)

Lunch (1.00 – 2.00 PM)    

         Biology Projects (Coordinator Dr Geetha Vani Rayasam)

  • Dr Sridhar Sivasubu & Dr Swati Subodh – Sequencing of MTb strains (2.00 -2.20
  • Dr Devendra Chauhan- JALMA MTb Strains (2.20 -2.30 PM)
  • Dr M Vijaylakshmi/Dr Sadhna Sharma/Dr Urmi Bajpai – Cloning and Expression of the select Mycobacterium Tuberculosis Genes (2.30 -2.50 PM)
  • Dr. K.K. Srivastava- Drug target based screens (2.50 – 3.10 PM)
  • Dr. Javed Aggrewala - Regression of the growth of M. tuberculosis by lipidated promiscuous peptide (3.10 - 3.30 PM)

Tea Break (3.30 - 4.00 PM)

  • Dr. Ashwini Kumar- System to validate protein-protein interactions (PPIs) (4.00 -4.20 PM)
  • Dr Gobardhan Das - Immunomodulation as a therapeutic approach (4.20 – 4.40 PM)
  • Dr Vinod Scaria – Chieminformatics and Genome Annotation (4.40 -5.00 PM)
  • Dr Debasis Dash - Mycobacterium tuberculosis GlmURv1018c as potential Drug Target (5.00 - 5.20 PM)
  • Dr Avinash Sonawane - Construction of GlmU mutants and Understanding the effect of Mutation or Deletion of C-terminus amino acid stretch involved in Protein-Ligand Interaction (5.20-5.40 PM)
  • Dr Balaji Prakash- Crystal structure analysis of GlmU (5.40-6.00 PM)
  • Dr B Siram: Design and synthesis of new inhibitors of Mycobacterium tuberculosis GlmU (6.00-6.20 PM)
  • Dr Vinay Nandicoori - Assay Development and Hit Identification for GlmU (6.20-6.40
  • Dr Y. Singh: Protein kinases as a drug targets in Mycobacteria (6.40-7.00 PM)
  • Dr Vinay Nandicoori: Assay Development and Hit Identification of PKNB inhibitors (7.00-7.20PM)
  • OSDD Students: Presentations and Interaction (7.20-8.00 PM)

     17th September 2011 , Venue: Science Centre, Gate No.2 Lodhi Garden

     Chemistry & Early Hit Identification (Coordinator Dr. Haridas Rode)

  • Dr Tushar Chakraborty - Open Chemistry + Outreach program (10.00 – 10.20 AM )
  • Dr. Radhakrishnan – Outreach Program (10.20 – 10.40 AM )
  • Dr Anamik Shah - Organic synthesis (10.40 – 10.50 AM )
  • Dr Nagaraju - Exploring the medicinal plants of the Western Ghats for potential drug molecules that possess ant-microbial activity and synthesis of a few molecules derived from lead compounds (10.50 – 11.00 AM )
  • Dr S V Eeshwaran - Substituted Aryl/Biaryl Triazoles and Quinoxalines as pontential Anti-tubercularagents (11.00 – 11.10 AM )
  • Dr Anil Kumar - Small molecule inhibitors of Mycobacterial Menaquionine biosynthetic pathway enzymes as novel anti-TB drugs; Improved Chemical Entitites as Anti-Tubercular Agents Targeting the Respiratory Pathway through Co-Crystal Engineering (11.10 – 11.20 AM)
  • Rev Fr Dr S Ignacimuthu - Isolation of antimycobacterial compounds vasicine acetate and 2-acetyl benzylamine from adhatoda vasica and synthesis (11.20 –11.30 AM )

 Tea Break (11.30 – 11.50 AM)

  • Dr Pemaiah Brindha - Screening of Anti-Tubercular Compounds from Plant Resources (11.50– 12.00 Noon)
  • Dr Saraswathi R – Nano particle based drug delivery (12.00 -12.10 PM)
  • Dr. Surinder Koul - MDR resistant efflux pump Rv1258c of Mtb (12.10 -12.30 PM)
  • Dr G.P.S Raghav: Prediction of Dap A and Dap B inhibitors (12.30-12.50 PM)
  • Dr S. Ramachandran: Development of assays for Dap A and Dap B (12.50-1.10 PM)
  • Dr Bala Pesala/Dr Ashwini Kumar: Non invasive optical TB diagnostics (1.10-1.30
  • Dr. Saman Habib: OSDD – Malaria (1.30-1.50 PM)

Thursday, September 8, 2011


Meeting was held today for collborative OSDD Cheminformatics work between
1. Professor David wild(Associate Professor & Director of cheminformatics Program  Indiana Univerrsity bloomington) ,
2. Zakir thomas(OSDD Project Director ) ,
3 Dr UC Abdul Jaleel(Associate Professor of cheminformatics Malabar christian college & Principal Investigator of the       OSDD cheminformatics) and
4 Abhik Seal(PhD scholar  at Indiana University Bloomington & OSDD cheminformatics group 1 leader)

The following important points have been discussed  by the people:

Prof David Wild:

Prof david gave a  brief idea about the cheminformatics and chemgenomics research going on in his lab and about the PXR project with university of Cincinnati  . He also discussed about the chembio2Rdf repository and the semantic web technologies involved in his research and how he would like to develop tools for chemgenomics and cheminformatics research.

Zakir thomas:

Dr Zakir thomas gave a brief idea about what OSDD is and how OSDD is collaborating with the graduate students and discussed the why osdd is needed to get started in india .He also discussed the difference between osdd and other open source models that exist . OSDD is basically runned by the graduate students from any subject area ,researchers, and institutes.

Dr. Abdul Jaleel:

Dr Jaleel discussed the problems now we are facing in OSDD cheminformatics mainly related to the following area in Clustering compounds with molecular diversity , designing quantum chemical descriptors  and building semantic chemical biology framework for OSDD data.
I hope Collaborative cheminformatics with osdd and Indiana takes a postive side for future prospects.


Abhik Seal
Indiana University Bloomington
Department of Chemical Informatics
            +18123699097 begin_of_the_skype_highlighting            +18123699097      end_of_the_skype_highlighting

Monday, September 5, 2011

WORK SHOP -Monitoring and Evaluation of Recalcitrant Chemicals in the Environment

Dear OSDD members, 

 Very happy to inform you that we are organizing a National LevelTraining Workshop on Monitoring and Evaluation of Recalcitrant Chemicals in the Environment(MERE '11) during 28th - 31st October 2011. The main focus of the workshop is to impart hands on training on the analysis of emerging pollutants in the environmental samples using GC-MS (Gas Chromatograph - Mass Spectrometer) for detection and quantification of pollutants. Herewith I have attached the event brochure for more details. Kindly circulate this information among your department people and friends circle.  
Event contact details: 
Dr. R. Babu RajendranOrganizing Secretary - MERE '11
Dept. of Environmental Biotechnology
School of Environmental Sciences
Bharathidasan University
Tiruchirappalli - 620024
Tamil Nadu, India
Mobile: 09442105438

Please do not hesitate to contact us through e-mail or mobile for further information.

Thanking you,
OSDD DECODE2-Cheminformatics Group

Research scholar 
lDept. of Environmental Biotechnology
Bharathidasan University
Tamil Nadu
Ph: 9952520536

Sunday, September 4, 2011



The departments of life sciences of Shankarlal Khandelwal College Akola have planned to organize a National Conference on advances in life sciences for sustainable Rural Development on 11th & 12th October 2011. In recent years, rural development has become the focus of attention in countries around the world. It is one of the most important item in the development agenda of India, whose seventy percent of population is dependent upon agriculture for livelihood. Development of villages without harming the integrity of their traditional wealth and peaceful environment is the need of 21st century. Many of the developmental issues of villages are related with the applied aspects of life sciences such as Biogas, Biofertilizers, Biopesticides, Organic manures, Medicinal plants, Plant tissue culture, Floriculture, Animal husbandry, Aquaculture, Sericulture, Apiculture, Vermiculture and many other aspects of Agricultural biotechnology. This National Conference is intended to offer an opportunity to all concerned including students, teachers, researchers and scientists from different parts of India to exchange the ideas and views regarding the latest technological advances in life sciences for sustainable rural development.
Tue, October 11, 10:00am – Wed, October 12, 5:30pmGMT+05:30
for details

Thursday, September 1, 2011

Medicinal chemistry related to Antimalarials

Dear All,

Ganpati Bappa Morya

I am pleased to announce that CSIR-CDRI will be organizing a one-day
symposium on developments in the medicinal chemistry related to
Antimalarials on 16th November 2011. The conference will be held under
the aegis of OSDD and will be funded by Medicines for Malaria Venture.
We expect to have Professor Stephen A Ward, Walter Myers Professor of
Parasitology, Deputy Director LSTM, Dr. Jeremy Burrows, Head,
Discovery Science, MMV here to discuss the developments of new
antimalarials. From Indian side Prof. Rahul Jain, Dr. K.
Muraleedharan, Prof. Hema Balram, Dr. Saman Habib will be delivering
talks beside other. We intend to have a 2-3 talks by younger
participants (may be research scholars) working in the field of
development of new antimalarials. In order to encourage wider
participation we intend to have only token registration money. We will
be soon posting the details of the symposium on the cdri website. We
request you to circulate the information amongst your colleagues for a
wider participation.

Thanking you and with kind regards,


Dr SANJAY  member OSDD organic chemistry forum

Monday, August 29, 2011


Dr K. M. Muraleedharan &
Dr Nandita Madhavan
[Conveners, MedChem 2011]

Dear all,

We are happy to inform you that the Department of Chemistry, IIT Madras is organizing a symposium MEDCHEM 2011 focusing on ‘Anti-Infective Drug Discovery and Development’ during October 28-29, 2011. This is the second conference of its kind since AstraZeneca and IIT Madras joined hands to promote medicinal chemistry education in the country. MEDCHEM 2011 will have 15 stimulating lectures on areas such as target identification, drug synthesis, target validation, lead identification, lead optimization, and clinical development by distinguished speakers from academia and industry. The conference will also showcase ongoing medicinal chemistry research in the country through poster presentations from scientists and students on the first day. The conference aims to bring together practicing medicinal chemists and young students on a common platform. . Participation can be through a poster presentation or as an attendee. More details about the conference are available on our website

We look forward to your active participation in this event.


Muraleedharan and Nandita Madhavan
Dr. Muraleedharan K.M.,
Assistant Professor,
Department of Chemistry,
IIT Madras.
Phone:             +91-44-2257 4233 begin_of_the_skype_highlighting            +91-44-2257 4233      end_of_the_skype_highlighting      
fax: +91-44-2257 4202

Dr Muraleedharan - member OSDD organic chemistry forum